{"id":10763,"date":"2025-08-01T06:31:41","date_gmt":"2025-08-01T11:31:41","guid":{"rendered":"https:\/\/ibio.org\/?p=10763"},"modified":"2025-08-08T06:32:55","modified_gmt":"2025-08-08T11:32:55","slug":"clostrabios-next-gen-probiotic-clears-safety-hurdle","status":"publish","type":"post","link":"https:\/\/ibio.org\/clostrabios-next-gen-probiotic-clears-safety-hurdle\/","title":{"rendered":"ClostraBio&#8217;s Next-Gen Probiotic Clears Safety Hurdle"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Chicago biotech startup ClostraBio has <a href=\"https:\/\/www.businesswire.com\/news\/home\/20250729574134\/en\/ClostraBio-Inc.-Obtains-Self-Affirmed-GRAS-Status-for-Next-Gen-Probiotic-Ingredient-CLB101\">secured GRAS<\/a> (Generally Recognized as Safe) status for its flagship probiotic ingredient CLB101\u2122, clearing the path for the first commercially available strain of Anaerostipes caccae in the U.S.<\/span><\/p>\n<p class=\"p1\"><strong><span class=\"s3\">What Makes It Different<\/span><\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">Unlike traditional probiotics, CLB101\u2122 produces butyrate directly in the lower intestine. This beneficial compound strengthens the intestinal barrier, supports immune function, and promotes a diverse microbiome\u2014all critical for gut health.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The strain, isolated from healthy humans, underwent rigorous safety testing including genomic characterization and multiple toxicology studies before receiving expert panel approval.<\/span><\/p>\n<p class=\"p1\"><strong><span class=\"s3\">Market Launch<\/span><\/strong><\/p>\n<p class=\"p1\"><span class=\"s1\">ClostraBio plans to launch CLB101\u2122 as a supplement this fall through direct sales and partnerships, including a collaboration with a leading healthcare practitioner-focused brand.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">&#8220;This recognition reinforces our commitment to advancing safe, science-driven solutions that can help support gut health,&#8221; said CEO Ritu Shah.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Spun out from the University of Chicago, ClostraBio&#8217;s first-to-market advantage with Anaerostipes caccae positions it well as consumers increasingly seek targeted, research-backed gut health solutions.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chicago biotech startup ClostraBio has secured GRAS (Generally Recognized as Safe) status for its flagship probiotic ingredient CLB101\u2122, clearing the path for the first commercially available strain of Anaerostipes caccae in the U.S. What Makes It Different Unlike traditional probiotics, CLB101\u2122 produces butyrate directly in the lower intestine. This beneficial compound strengthens the intestinal barrier, [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[145,526],"tags":[262,202,121,122,285],"class_list":["post-10763","post","type-post","status-publish","format-standard","hentry","category-community-news","category-newsbrief","tag-chicago","tag-clostrabio","tag-illinois","tag-life-sciences","tag-startup"],"_links":{"self":[{"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/posts\/10763","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/comments?post=10763"}],"version-history":[{"count":1,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/posts\/10763\/revisions"}],"predecessor-version":[{"id":10764,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/posts\/10763\/revisions\/10764"}],"wp:attachment":[{"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/media?parent=10763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/categories?post=10763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibio.org\/wp-json\/wp\/v2\/tags?post=10763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}